Hardening of the arteries (atherosclosis), due to risk factors such as smoking, uncontrolled high blood pressure, high fat diet, diabetes and high cholesterol, commonly occurs in the legs and cause symptoms of cramping and fatigue in the calves, thighs or hips with ambulation. This syndrome is called “intermittent claudication”, and as the narrowing of the arteries (PVD, or Peripheral Vascular Disease) worsens, the distance that can be walked without pain decreases. Ultimately, with severe PVD, ulcerations, tissues loss or eventually gangrene can ensue…..potentially leading to minor or major amputations. Early control of the aforementioned risk factors, coupled with a graded exercise program and pharmacologic intervention, can forestall or even improve this syndrome, by enabling the human body’;s natural mechanisms to develop collaterals or side channels around the blockages in the arteries. Early detection, careful diagnosis, appropriate non-invasive testing and aggressive conservative management by the patient and our professional staff are crucial to managing this disease.